Bextra, the drug chemically known as valdecoxib, is a COX-2 Inhibitor drug used primarily to alleviate the painful inflammation common to many forms of arthritis. Like similar medications Vioxx and Celebrex, it is designed to reduce pain, swelling, and fever without irritating the stomach and lower digestive tract like aspirin and other NSAIDs (N
on-Steroidal Anti-Inflammatory Drugs).
NSAIDs work by effectively blocking a chemical in the body called cyclooxygenase, of which there are two main derivatives. Cyclooxygenase-1, or COX-1, shields the stomach from the harsh hydrochloric acid it contains, and Cyclooxygenase-2, or COX-2, is found in inflamed tissues and causes the pain of fever, infection, and arthritis. The drugs were effective for alleviating the pain and inflammation but the relief benefits were limited because the traditional NSAIDs caused stomach irritation. Taking an NSAID like aspirin caused discomfort because it blocked both chemicals, relieving pain but also disabling the stomach protection of COX-1.
on-Steroidal Anti-Inflammatory Drugs).NSAIDs work by effectively blocking a chemical in the body called cyclooxygenase, of which there are two main derivatives. Cyclooxygenase-1, or COX-1, shields the stomach from the harsh hydrochloric acid it contains, and Cyclooxygenase-2, or COX-2, is found in inflamed tissues and causes the pain of fever, infection, and arthritis. The drugs were effective for alleviating the pain and inflammation but the relief benefits were limited because the traditional NSAIDs caused stomach irritation. Taking an NSAID like aspirin caused discomfort because it blocked both chemicals, relieving pain but also disabling the stomach protection of COX-1.
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